从Azotobacter chroococcum中提取的酸盐装载在纳米颗粒中:关于特征,抗真菌和抗癌活性的洞察
Hebah A Sindi1, Ragaa A Hamouda2,3, Marwa S Abdel-Hamid3
1Department of Biological Sciences, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.
Polymers
|July 27, 2024
概括
这项研究开发了来自Azotobacter sp.的纳米颗粒 (Alg-Se-NCMs). 这些纳米颗粒显示出有前途的抗真菌和抗癌活性,为感染和癌症提供了潜在的新疗法,副作用较少.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 抗菌研究 抗菌研究
背景情况:
- 对癌症的化疗有显著的副作用.
- 抗生素耐药性的增加需要新的抗菌战略.
- 自然化合物为向药物输送提供了潜在的潜力.
研究的目的:
- 为了隔离阿佐托巴克特 sp. 和提取阿尔金酸盐.
- 为了制造纳米粒子 (As/Se-NPs) 和含酸盐的纳米粒子 (Alg-Se-NCMs).
- 为了评估As/Se-NPs和Alg-Se-NCMs的抗真菌和抗癌特性.
主要方法:
- 隔离和识别的阿佐托巴克特菌 sp.
- 提取酸盐和制造As/Se-NPs使用酸.
- 使用TEM,EDX,UV-Vis,FT-IR和泽塔潜力对纳米粒子进行表征.
- 抗真菌检测对抗黑色菌,烟菌,新型菌,白菌和菌.
- 对HCT-116结肠直肠和Hep G2肝癌细胞系进行抗癌检测.
主要成果:
- 作为/Se-NPs和Alg-Se-NCMs已经成功合成和表征.
- 紫外线光谱显示了269和296nm的表面等离子体共振.
- 泽塔电位表示负面电荷 (-37.2和-38.7mV).
- 纳米粒子呈现出六角形状,尺寸从16.52到97.06nm不等.
- Alg-Se-NCMs对HCT-116和Hep G2细胞表现出显著的抗癌活性.
- Alg-Se-NCMs对Cryptococcus neoformans和Aspergillus niger显示出强大的抗真菌活性.
结论:
- 酸覆盖的纳米粒子 (Alg-Se-NCMs) 是有效的抗真菌剂.
- Alg-Se-NCMs显示出有前途的抗癌特性.
- 这些新型纳米粒子代表了对真菌感染和癌症治疗的潜在治疗策略.
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