生物活性化合物在粉-聚乙烯糖醇修饰微粒中的保护性封装:用酶进行降解分析
Karen Sofia Valenzuela Villela1,2, Karen Valeria Alvarado Araujo1, Perla Elvia Garcia Casillas3
1Grupo de Investigación Nanomedicina, Instituto de Ingeniería y Tecnología, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez 32310, Mexico.
Polymers
|July 27, 2024
概括
用聚乙烯糖醇 (PEG) 修改的粉微粒被制造成封装叶酸. 这些生物相容的微粒体显示出有效的酶降解,显示出对受控药物递送系统的前景.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
背景情况:
- 粉是一种生物相容的聚合物,具有药物输送潜力.
- 微粒子系统提供受控释放能力.
- 聚乙烯甘醇 (PEG) 修改可以增强材料性能.
研究的目的:
- 为了合成和表征PEG修饰的粉微粒封装叶酸.
- 在模拟生理条件下评估这些微粒的酶降解.
- 评估PEG粉微粒对于控制药物输送和生物医学应用的适用性.
主要方法:
- 溶剂介导的酸沉与磁用于微粒子合成.
- 里埃变换红外光谱 (FTIR) 和扫描电子显微镜 (SEM) 用于表征.
- 在生理条件下使用氨酶和素进行酶降解试验.
主要成果:
- 通过FTIR和SEM证实粉-PEG微粒封装叶酸的成功合成.
- 平均颗粒大小为4.97微米,在PEG修改后增加到6.01微米.
- 酶降解导致粒子大小,形态和FTIR光谱的变化,表明分解.
结论:
- 经PEG改性粉微粒有效合成并封装叶酸.
- 微粒对酶降解具有敏感性,这对于体内应用至关重要.
- 这些发现支持PEG粉作为用于药物输送和封装生物活性化合物的多功能生物材料的发展.
关键词:
氨基酸氨基酶是什么生物材料是一种生物材料.降解降解降解降解降解降解.药物输送是药物输送的过程.酵素酶是一种酶.叶酸是一种叶酸.微封装是一种微封装方式.佩普辛 (pepsin) 是一种可怕的药物.聚乙烯糖醇是一种聚乙烯糖醇.这是一种粉,粉.更多相关视频
07:32Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
11.3K
06:36Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
Published on: September 8, 2021
2.7K
相关概念视频
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
332
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
332
01:28Biodeterioration
84
Biodeterioration refers to the unwanted alteration of materials caused by microorganisms—especially fungi—which damage both organic substrates (paper, wood, textiles) and inorganic ones (stone, plaster, glass). Unlike abiotic decay, biodeterioration results from biological activity that produces physical disruption and chemical degradation.Physical deterioration occurs as fungal hyphae penetrate pores, cracks, and surface irregularities. Hyphal turgor pressure, thigmotropic growth...
84