热稳定聚乙醇) 纳米纤维材料由可扩展电制成:在组织工程中的应用
W Joseph A Homer1,2, Maxim Lisnenko3, Sarka Hauzerova3
1Engineering for Health Research Centre, College of Engineering and Physical Sciences, Aston University, Birmingham B4 7ET, UK.
Polymers
|July 27, 2024
概括
聚乙醇) 电纳米纤维为组织工程支架提供了有希望的,更绿色的替代品. 较高的水解度产生更强,更结晶的纤维,在4-8小时的热处理后观察到最佳的增殖.
科学领域:
- 生物材料科学 生物材料科学
- 材料工程 材料工程 材料工程
- 组织工程是组织工程.
背景情况:
- 电产生纳米纤维支架,模仿自然的细胞外基质,用于组织工程.
- 聚乙醇 (PVA) 是一种用于创建这种支架的多功能聚合物.
研究的目的:
- 研究聚乙烯醇 (PVA) 电纳米纤维作为组织工程支架的潜力.
- 评估不同程度的水解和热处理对PVA纳米纤维特性和生物相容性的影响.
主要方法:
- 无针直流电PVA的98%和99%的水解度.
- 在180°C的温度下进行高达16小时的热处理,以达到不溶性.
- 纤维形态,机械强度,结晶性,血液溶解,抗凝活动,血栓形成和纤维细胞增殖的表征.
主要成果:
- 与98%的水解相比,更高的水解 (99%) 产生了更薄,更强,更结晶的纤维.
- 长时间的热处理 (16小时) 降低了结晶性和抗拉强度,但保留了纤维形态.
- 脚手架显示出最小的血液溶解和抗凝剂活性;随着热处理,血栓形成增加.
- 在热处理4小时和8小时的支架上观察到最佳的纤维细胞增殖.
结论:
- 电PVA纳米纤维,特别是那些具有更高的水解度和优化热处理的纳米纤维,显示了组织工程应用的巨大潜力.
- 这些"更绿色"的支架为传统材料提供了替代品,并可以作为耐热添加剂的输送载体.
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