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在连续双螺丝湿颗粒处理过程中,评估聚乙烯酒精作为粘合剂
Phaedra Denduyver1, Gudrun Birk2, Alessandra Ambruosi2
1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
Pharmaceutics
|July 27, 2024
概括
聚乙醇 (PVA) 等级被评估为双螺丝湿颗粒 (TSWG) 的结合剂. PVA 4-88被证明是最有效的,在可溶和不可溶的配方中,在较低的液体/固体比率下产生强颗粒.
科学领域:
- 制药技术 制药技术 制药技术
- 化学工程是化学工程的重要组成部分.
- 材料科学 材料科学 材料科学
背景情况:
- 粘合剂的选择在连续双螺丝湿颗粒处理 (TSWG) 中非常重要,因为停留时间很短.
- 聚乙烯醇 (PVA) 4-88是有效的,但其他PVA等级需要对TSWG应用进行调查.
研究的目的:
- 评估不同等级的聚乙烯醇 (PVA) 作为TSWG中的结合剂的潜力.
- 为了研究在液化床干燥过程中含有各种PVA等级的药物加载颗粒的破裂和干燥行为.
主要方法:
- 三个PVA等级 (4-88,18-88,40-88) 的特征.
- 使用主要成分分析 (PCA) 进行了结合剂属性的比较.
- 评估了颗粒的特性,包括破裂,干燥和片的强度.
主要成果:
- 对于水溶性和水不溶性配方,PVA 4-88是最有效的粘合剂.
- 所有PVA等级在不溶于水的配方中都表现出更高的有效性,在较低的液体/固体 (L/S) 比率下产生强颗粒.
- 在液化床干燥过程中,PVA等级促进了对乙氨基 (APAP) 颗粒的快速干燥,无需磨损.
结论:
- 聚乙醇 (PVA) 是双螺丝颗粒化 (TSWG) 的高效粘合剂,特别是在低L/S比率下,可实现高效的加工.
- 聚乙烯等级对可溶和不可溶的配方都有优势,特别是在减少液体添加的情况下获得强大的颗粒.
- 使用PVA的工艺稳定性需要仔细控制辅助剂,因为运行时L/S比率范围狭窄.
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