推进瘤治疗:基于蛋白质的纳米粒子的开发和利用
Shirin Khakpour1, Nushin Hosano2, Zahra Moosavi-Nejad3
1Graduate School of Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
Pharmaceutics
|July 27, 2024
概括
基于蛋白质的纳米粒子 (PNPs) 提供有前途的瘤治疗,具有有针对性的输送和低毒性. 本综述将PNP生产方法分为溶解度变化,溶剂替代和薄流技术,以提高理解和应用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 基于蛋白质的纳米粒子 (PNPs) 对于晚期癌症治疗至关重要,因为它们的向传递,低毒性和可调性特征.
- 有效的生产方法对于在各种生物医学应用中利用PNP至关重要,例如药物输送,成像和组织工程.
研究的目的:
- 审查和分类生产基于蛋白质的纳米粒子 (PNPs) 和它们的药物复合物的现有和新方法.
- 为了解PNP生产机制和影响因素提供一个明确的框架.
主要方法:
- 将PNP生产技术分为三个类别:溶解度变化,溶剂替代和薄流方法.
- 分析每个方法的基本原则,影响因素 (大小,形态,稳定性,功能) 和挑战 (可扩展性,可重复性,生物相容性).
主要成果:
- 与其他系统相比,拟议的分类为PNP生产提供了简化和有利的理解.
- 详细讨论与溶解度变化,溶剂替代和薄流方法相关的优点和局限性.
结论:
- 了解PNP生产方法是推动其在瘤治疗和其他生物医学领域应用的关键.
- 新兴趋势和创新策略有望克服当前的局限性,推动PNP技术的未来发展.
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