配方 开发用于局部递送的梅洛西卡姆二进制以索姆水凝:体外和体外评估
Ahdaq Ali Faisal Al-Ameri1, Fatima Jalal Al-Gawhari2
1Iraqi Ministry of Health, Nasiriya 64001, Iraq.
Pharmaceutics
|July 27, 2024
概括
二元乙体水凝提供了MLX的增强局部传递,提高了溶解度和皮肤透度,同时减少了与经典乙体相比的副作用.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 梅洛西卡姆 (MLX) 在局部应用中具有较差的溶解性和生物可用性.
- 传统的输送系统往往会导致系统性不良事件.
- 乙组为改善皮肤药物递送提供了潜力.
研究的目的:
- 为了制定和表征一种新的MLX二元乙体水凝,用于增强局部输送.
- 为了评估皮肤透,抗炎疗效,并将其与经典的ethosomes进行比较.
- 通过使用Box-Behnken设计优化MLX以组的配方.
主要方法:
- 通过热方法制备的MLX乙索体,使用Box-Behnken设计进行优化.
- 描述包括囊泡大小,分散指数,封装效率和泽塔潜力.
- 水凝配方,风湿学评估,体外药物释放,体外透和体内抗炎研究.
主要成果:
- 优化MLX以太体 (MLX-Ethos-OF) 显示了有利的特征:大小为169nm,0.2DI,EE为83.1%,zeta电位为-42.76mV.
- MLX-Ethos-OF水凝表现出理想的物理,质和皮肤相容性质.
- 活体透流量 (70.45μg/cm2/h) 和体内抗炎作用 (53.2%) 显著超过了经典的类型.
结论:
- 二元乙体水凝为局部MLX输送提供了一个高效的系统.
- 这种配方增强了药物的溶解性,皮肤透性和治疗功效.
- 对于MLX局部传递,二进制乙体比经典乙体更为优越.
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