通过非聚合物无聚合物电制成的β-环氧化-甲酸衍生物来制造Enrofloxacin制药配方
Diana-Andreea Blaj1,2, Cătălina Anișoara Peptu2, Maricel Danu2
1"Petru Poni" Institute of Macromolecular Chemistry, 700487 Iasi, Romania.
Pharmaceutics
|July 27, 2024
概括
新型药物配方通过使用循环德克斯-奥利戈拉克提德 (CDLA) 衍生物来增强恩罗夫洛克萨 (ENR) 输送. 这些新型的电纳米纤维维持ENR.
科学领域:
- 兽医药理学 兽医药理学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 诺基诺抗生素Enrofloxacin (ENR) 在兽医应用中面临着水溶性差和生物可用性低的挑战.
- 现有的配方策略,如固体分散和纳米悬浮具有局限性.
- 需要新的方法来提高ENR的治疗疗效.
研究的目的:
- 开发使用定制制备的循环德克斯林-奥利戈拉克提德 (CDLA) 衍生物的新型恩罗夫洛克萨 (ENR) 配方.
- 为了研究ENR与CDLA衍生物的无聚合物共电的可行性.
- 评估开发的ENR-CDLA配方的抗菌疗效.
主要方法:
- 恩洛夫洛克萨 (ENR) 与定制制备的循环德克斯林-奥利戈拉克提德 (CDLA) 衍生物的联合电.
- 在纳米纤维网中优化电参数,以实现高ENR纳入纳米纤维网.
- 使用FTIR和NMR光谱学进行表征.
- 在体外对黄金葡萄球菌,大肠杆菌和 Pseudomonas aeruginosa 的抗菌活性进行测试.
主要成果:
- 通过联合电成功开发了无聚合物ENR载荷的CDLA纳米纤维网.
- 在纳米纤维配方中实现了高达15.6%的ENR重量.
- 鉴定证实了ENR在CDLA矩阵中的成功集成.
- 证明ENR对已测试的细菌菌株保持抗菌活性.
结论:
- 恩洛夫洛克萨 (ENR) 与环氧德克斯-奥利戈拉克提德 (CDLA) 衍生物的联合电是一种可行的方法,用于创建先进的药物递送系统.
- 开发的ENR-CDLA纳米纤维配方有效地结合了高药物负载,而不会影响抗菌活性.
- 这些配方有望改善兽医抗生素治疗,需要进一步研究.
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