治愈植物和虫的药物潜力,用于治疗炎症性肠病
Tenzin Jamtsho1,2, Alex Loukas2, Phurpa Wangchuk1,2
1College of Public Health, Medical, and Veterinary Sciences (CPHMVS), Cairns Campus, James Cook University, Cairns, QLD 4878, Australia.
Pharmaceuticals (Basel, Switzerland)
|July 27, 2024
概括
原住民药用植物和虫在治疗炎症性肠病 (IBD) 方面表现有前途. 研究强调它们的抗炎功能,天然化合物为IBD管理提供更安全的治疗选择.
科学领域:
- 自然产品化学和免疫学
- 民族植物学和寄生虫学
- 药物的发现和开发.
背景情况:
- 炎症是诸如炎症性肠病 (IBD) 等疾病的关键因素,这种慢性疾病影响全球数百万人.
- 在历史上,土著人口一直在使用天然疗法治疗各种疾病,包括IBD.
- 虫及其产品具有独特的免疫调节特性,对炎症状况有益.
研究的目的:
- 审查土著药用植物和虫治疗IBD的药物潜力.
- 为了突出最近在识别抗炎小分子药物方面的进展,从自然来源引入自然来源.
- 探索天然产品和虫在治疗IBD中的治疗应用.
主要方法:
- 在主要的科学数据库 (Scopus,PubMed,科学网等) 中进行文献搜索. ) 的情况.
- 基于关键字的检索,重点是天然产品,小分子,细胞因子,药用植物和虫.
- 分析利用动物模型和体外细胞测试来评估抗炎性质的研究.
主要成果:
- 确定了55种土著药用植物和9种虫物种,具有研究的抗炎性质.
- 突出显示的化合物包括来自植物的黄素,柏柏林和三类,以及虫分泌产品.
- 与传统治疗相比,具有抗炎活性,毒性可能较低,副作用较少.
结论:
- 原住民药用植物和虫为IBD治疗提供了重要的药物潜力.
- 自然化合物和虫衍生产品显示出作为更安全的抗炎剂的前景.
- 进一步的可重现的临床和机制研究对于验证这些IBD的自然疗法至关重要.
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