整合自然深层欧特基溶剂到纳米结构的脂质载体:一个工业的外观
Luísa Schuh1,2,3, Luane Almeida Salgado1,2,3, Tathyana Benetis Piau4
1Cooil Cosmetics, Brasília 72622-401, DF, Brazil.
Pharmaceuticals (Basel, Switzerland)
|July 27, 2024
概括
这项研究开发了环保的纳米结构脂质载体 (NLCs) 和使用天然深度溶解剂 (NaDES) 的NLCs. 这些可持续的纳米载体具有较低的细胞毒性,提供更绿色的工业替代品.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 绿色化学 绿色化学
背景情况:
- 越来越多的环境问题促使行业寻求可持续的替代方案来减少废物.
- 传统的生产方法往往会产生缺乏工业用途的副产品.
- 对于各种应用,需要环保和可定制的纳米载体系统.
研究的目的:
- 开发和描述两种类型的稳定纳米结构脂质载体 (NLC):一种标准配方和一种结合天然深度溶解剂 (NaDES).
- 研究开发的NLCs的物理化学特性,形态学和细胞毒性潜力.
- 探索不同的冷却技术,以适应工业用途的NLC特性.
主要方法:
- 使用 NaDES 制定标准的 NLC 和 NLC.
- 使用动态光散射 (DLS),泽塔电位,pH,传输电子显微镜 (TEM) 和共聚焦显微镜进行表征.
- 用纤维细胞L132细胞进行体外细胞毒性测试 (MTT,细胞谱) 和用斑马鱼进行体内测试.
- 使用红外光谱学和X射线衍光学分析物理化学性质.
主要成果:
- 通过NaDES成功制备稳定的NLC和NLC.
- 详细的形态和物理化学表征证实了纳米载体的特性.
- 在体外和体外模型中显示出低细胞毒性潜力.
- 冷却技术的探索揭示了适合工业应用的可定制性质.
结论:
- 该研究成功开发了新的,可持续的和环保的纳米载体 (NLC和NADES的NLC).
- 开发的纳米载体具有可定制性质和低细胞毒性潜力,适合各种工业应用.
- 这项技术代表了绿色化学和可持续材料开发的重大进步.
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