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Updated: Jun 18, 2025

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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设计用于口味掩饰儿科配方的梅弗洛基因树脂复合物的固态NMR特征

Leandro B Borré1, Eduardo G R Sousa2, Rosane A S San Gil1,3

  • 1Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, RJ, Brazil.

Pharmaceuticals (Basel, Switzerland)
|July 27, 2024
PubMed
概括

开发适用于儿童的抗疟疾药物至关重要. 将美弗洛基因与离子交换树脂结合,有效地掩盖了它的苦味,改善了儿童的药物管理.

关键词:
在13C NMR中.在CPMAS NMR中使用.T1ρH 放松时间电子舌头是一种电子舌头.离子交换树脂 离子交换树脂梅弗洛基因 (mefloquine) 是一种药物.味道掩饰是一种口味掩饰.

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Chemical Shift: Internal References and Solvent Effects01:17

Chemical Shift: Internal References and Solvent Effects

In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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NMR Spectroscopy: Chemical Shift Overview01:15

NMR Spectroscopy: Chemical Shift Overview

The position of the absorption signal of a sample is reported relative to the position of the signal of tetramethylsilane (TMS), which is added as an internal reference while recording spectra. The difference between the absorption frequencies of the sample and TMS (in Hz) is divided by the spectrometer operating frequency (in MHz) to obtain a dimensionless quantity called the chemical shift. It is reported on the δ (delta) scale and expressed in parts per million.
For instance, the proton...
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