美公园的抗菌和抗癌特性 叶子提取物
Mushtaq Ahmad Mir1, Lamis Ahmad Memish1, Serag Eldin Elbehairi2
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 3665, Abha 61421, Saudi Arabia.
Pharmaceuticals (Basel, Switzerland)
|July 27, 2024
概括
乙醇叶提取物Myrtus communis表现出显著的抗菌和抗癌性质. 这种天然化合物有效地抑制了菌根细菌的生长,并消除了生物膜,同时还在各种癌症细胞系中诱导了细胞亡.
科学领域:
- 药理学 药理学是指药理学的学科.
- 植物化学 植物化学
- 微生物学 微生物学
背景情况:
- 植物提取物在传统医学中用于治疗感染.
- 地中海草药Myrtus communis在全世界有着悠久的药用历史.
研究的目的:
- 为了评估Myrtus communis树叶提取物的抗菌和抗癌潜力.
- 为了研究提取物对菌根细菌生长,生物膜形成和癌细胞增殖的影响.
主要方法:
- 微板标志蓝色测定,井扩散和双盘扩散方法用于抗菌细菌活性和协同作用测试.
- 使用水晶紫色,硫胺-B测定和DNA流细胞测量来评估生物膜发育,细胞增殖和细胞循环停止.
- 安素V-FITC/PI标记和流动细胞计分析了癌细胞的亡和亡阶段.
主要成果:
- 乙醇的Myrtus communis提取物表现出显著的剂量依赖的菌根菌生长抑制 (MIC:4.88-312.5μg/mL).
- 提取物有效地抑制了生物膜的形成 (MBIC:9.7μg/mL) 并消除了成熟的生物膜 (MBEC:78-156μg/mL).
- 提取物通过诱导亡和G1细胞周期停止,对乳腺,肝脏,子宫和结肠癌细胞系 (IC50:33.3-83μg/mL) 显示出强大的抗癌作用.
结论:
- (Myrtus communis) 叶片提取物作为具有抗菌和抗癌活性的天然化合物的来源,显示出有前途.
- 进一步开发这种提取物可能会导致针对菌根菌感染和各种癌症的新型治疗剂.
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