塞夫托洛 - 塔佐巴克坦与腹腔营养的物理化学兼容性
Jan Thomas De Pourcq1,2,3, Adria Riera4, Laura Gras1,3
1Department of Pharmacy, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, 08025 Barcelona, Spain.
Pharmaceuticals (Basel, Switzerland)
|July 27, 2024
概括
塞夫托洛-塔扎巴克坦 (CT) 在Y位处方期间与腹腔营养 (PN) 兼容. 这项研究证实了同时接受两种治疗的危急患者的物理化学稳定性.
科学领域:
- 临床药房 临床药房
- 药物兼容性研究 药物兼容性研究
- 密集护理医学 密集护理医学
背景情况:
- 塞夫托洛-塔扎巴克坦 (CT) 治疗复杂的感染,包括来自多药耐药细菌的感染.
- 对于重症患者,可能需要同时给予CT和肠外营养 (PN).
- 对于CT与PN在Y位点同时使用的兼容性尚未得到充分证实.
研究的目的:
- 评估Ceftolozane-tazobactam (CT) 的物理化学兼容性,当通过Y部位与肠道营养 (PN) 联合使用时.
- 在模拟的临床环境中评估CT在玻尿酸和连续输液策略下的兼容性.
主要方法:
- 评估CT-PN混合物的视觉和显微镜外观,pH值和度.
- 通过使用动态光散射来确定平均脂质滴径 (MDD).
- 在24小时内使用HPLC-HRMS量化CT度.
主要成果:
- 在CT-PN添加剂中没有观察到视觉或微观变化.
- pH 变化很小 (≤0.2),度变化小于 5%.
- 平均脂质滴径保持稳定,低于500纳米,CT度在24小时内始终保持在可接受范围内,这两种输液方法均适用.
结论:
- 在模拟Y位处方过程中,Ceftolozane-tazobactam (CT) 已被证明是与亲肠营养 (PN) 的物理化学兼容.
- 这些发现支持在经过测试的条件下,在重症监护机构安全地同时使用CT和PN.
- 这项研究为优化复杂患者群体的药物治疗方案提供了关键数据.
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