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Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

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Updated: Jun 19, 2026

Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
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小动物模型研究简单疹病毒感染.

Mohammed Tanveer Hussain1, Brent A Stanfield1, David I Bernstein2

  • 1Division of Biotechnology and Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.

Viruses
|July 27, 2024
PubMed
概括

动物模型对于研究简单疹病毒 (HSV-1和HSV-2) 感染和评估新治疗方法至关重要. 本综述总结了用于HSV病原和治疗研究的常见动物模型.

关键词:
动物模型动物模型几内亚猪模型模型简单疹病毒 (HSV) 病毒人类疹病毒人类疹病毒鼠标模型 鼠标模型一些子模型.

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Last Updated: Jun 19, 2026

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科学领域:

  • 病毒学 病毒学
  • 免疫学 免疫学 免疫学
  • 传染性疾病 传染性疾病
  • 动物模型 动物模型

背景情况:

  • 简单疹病毒1型 (HSV-1) 和2型 (HSV-2) 在全球普遍存在,导致各种疾病,如生殖器疹,脑膜炎和角膜炎.
  • 高血清阳性率 (HSV-1:~90%,HSV-2:~20-25%) 和无症状感染使人类疾病研究复杂化.
  • HSV的神经向性质在理解人类病原发生方面带来了挑战.

研究的目的:

  • 审查和总结用于研究HSV的常用动物模型.
  • 讨论这些模型在理解HSV病变,疾病进展和宿主反应方面的应用.
  • 突出动物模型在新型HSV疗法和疫苗临床前评估中的作用.

主要方法:

  • 对HSV研究的动物模型建立文献的审查.
  • 通常使用的动物物种的识别和分类 (例如老鼠,豚鼠,子).
  • 讨论影响模型结果的关键变量,包括物种,感染途径,病毒菌株和剂量.

主要成果:

  • 几种动物模型,包括小鼠,豚鼠和子,已经为HSV研究建立了良好的基础.
  • 这些模型允许对HSV生物学,病原和宿主免疫反应进行调查.
  • 动物模型作为潜在的抗病毒药物和疫苗的初步评估的关键平台.

结论:

  • 动物模型是促进对HSV感染的理解和开发有效干预措施的必不可少的工具.
  • 选择动物模型和实验参数对于成功的HSV研究至关重要.
  • 动物模型的持续使用和改进对于对抗HSV相关疾病至关重要.