性行为改变了COVID-19对动脉弹性的影响
Jared C Durieux1, Sokratis N Zisis2, Christian Mouchati2
1University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Viruses
|July 27, 2024
概括
长期的COVID显著影响血管健康,特别是在女性身上. 女性性别和COVID-19 (PASC) 后急性后果与较差的动脉弹性有关,这表明血管损伤风险增加.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 血管生物学 血管生物学
背景情况:
- COVID-19的长期血管效应仍未得到充分研究,特别是关于性别差异.
- COVID-19 (PASC) 后急性后果对幸存者的健康构成重大负担.
- 内皮功能障碍是COVID-19相关血管并发症的潜在机制.
研究的目的:
- 研究COVID-19对成年幸存者的血管功能长期影响.
- 评估COVID-19相关的血管损伤中的潜在基于性别的差异.
- 评估PASC与内皮功能之间的关系.
主要方法:
- 一项前性队列研究,比较了COVID-19幸存者 (COVID+) 和SARS-CoV-2抗体阴性对照 (COVID-).
- 使用FDA批准的EndoPAT进行非侵入性内皮功能评估.
- 倾向性得分匹配确保了平衡的基线共变量,包括性别.
主要成果:
- 与对照组相比,COVID-19幸存者表现出显著受损的内皮功能 (更高的增强指数,AI).
- 女性与更高的D-二聚合物和zonulin水平有关,这表明凝血和肠道透性增加.
- 患有PASC的COVID-19幸存者表现出最糟糕的内皮功能,女性患有PASC的AI最高.
结论:
- 感染SARS-CoV-2导致可测量的长期血管功能障碍.
- 女性性别和PASC的存在加剧了COVID-19对动脉弹性的负面影响.
- 针对性血管健康监测对于COVID-19幸存者至关重要,特别是患有持续症状的女性.
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