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定量HBV核心抗体作为HBeAg血清清除的预后标记:通过元分析进行系统审查

Ivana Lazarevic¹, Danijela Miljanovic¹, Ana Banko¹

¹Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.

|July 27, 2024

概括

定量乙型肝炎核心抗体 (qAnti-HBc) 可以预测慢性乙型肝炎患者的乙型肝炎e抗原 (HBeAg) 血清. 较高的基线qAnti-HBc水平与成功的HBeAg血清清除有关,有助于治疗评估.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
免疫学免疫学免疫学

背景情况:

乙型肝炎抗原 (HBeAg) 血清清除是慢性乙型肝炎病毒 (HBV) 感染的关键治疗终点.
预测HBeAg血清清除有助于评估HBV患者的治疗疗效.
测量HBV核心抗体 (qAnti-HBc) 是一个新兴的非侵入性生物标志物.

研究的目的:

系统地审查和分析评估qAnti-HBc在预测HBeAg血清清除中的作用的研究.
评估HBV患者的基线qAnti-HBc水平,这些患者已经达到或没有达到HBeAg血清.

主要方法:

来自PubMed,科学网和SCOPUS的研究的系统审查和元分析.
包括19篇与3434名慢性感染HBV患者的文章.
与HBeAg血清清除结果相关的qAnti-HBc水平的分析.

主要成果:

在获得HBeAg血清清除的患者中,基线qAnti-HBc水平显著更高 (SMD = 0.88,p < 0.001).
这一发现在亚洲人群中 (SMD = 0.94) 和治疗诱导的成年人血清清除 (SMD = 0.90) 中是一致的.

结论:

qAnti-HBc是一种有前途的非侵入性生物标志物,用于预测慢性HBV感染中HBeAg血清清除.
较高的基线qAnti-HBc水平表明获得HBeAg血清清除的可能性更高.
这种生物标志物可以帮助临床医生管理HBV治疗.

关键词:

肝炎病毒核心抗体在 HBeAg 血清清除过程中,乙型肝炎病毒 (HBV)qAnti-HBcc是一种抗HBc的药物.量化量化量是指量化的量.

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