通过"抗病毒"TRIM蛋白调节线粒体衍生的免疫激活
Seeun Oh1, Michael A Mandell1,2
1Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Viruses
|July 27, 2024
概括
三方基因含有 (TRIM) 蛋白调节线粒体在先天免疫和抗病毒防御中的作用. 它们控制线粒体免疫信号和线粒体,影响炎症和疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 病毒学 病毒学
背景情况:
- 线粒体对于先天性免疫反应和抗病毒信号传递至关重要.
- 线粒体可以释放免疫刺激分子,在病毒感染期间促进干扰素的产生.
- 损坏的线粒体可以不适当地触发免疫反应,模仿抗病毒反应.
研究的目的:
- 审查三方基因含有蛋白 (TRIM) 在调节基于线粒体的先天免疫激活中的作用.
- 探索TRIMs如何调节线粒体免疫信号传递和线粒体细胞衰变在抗病毒防御中的作用.
- 了解TRIMs在与线粒体炎症相关的疾病中的更广泛影响.
主要方法:
- 文献综述侧重于TRIM蛋白和线粒体抗病毒免疫力.
- 对TRIM蛋白在免疫信号转导通路中的功能进行分析.
- 检查TRIMs在线粒细胞和线粒体因子的去除中的作用.
主要成果:
- TRIM蛋白对于抗病毒防御至关重要,并调节线粒体介导的先天免疫力.
- TRIMs调节由线粒体分子激活的免疫信号通路.
- TRIMs协调线粒细胞衰变以去除线粒体和相关的免疫激活因子.
结论:
- 在天生的免疫力中,TRIM蛋白具有双重作用:抗病毒防御和调节基于线粒体的炎症.
- 在控制线粒体免疫激活方面,TRIMs的功能扩大了它们已知的作用.
- TRIMs的失调可能会导致与线粒体衍生的炎症相关的疾病.
相关概念视频
Immune Response Against Viral Pathogens
766
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
766
Cytotoxic T Cells-mediated Immune Response
865
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
865
Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
The Extrinsic Apoptotic Pathway
6.3K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.3K
Mitochondrial Precursor Proteins
2.6K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70 chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
Most of the mitochondrial...
2.6K


