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在SARS-CoV-2免疫接种后获得的血友病A:对罕见副作用的叙述性审查

Roberto Castelli¹, Antonio Gidaro², Roberto Manetti¹

¹Department of Medical Surgical and Pharmacology, University of Sassari, 07100 Sassari, Italy.

|July 27, 2024

概括

获得性血友病A (AHA) 是一种罕见的出血疾病,与第八因子抗体有关. 虽然COVID-19疫苗很少引发AHA,但它们在预防严重疾病方面的好处超过了这种风险.

科学领域:

血液学血液学血液学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

获得性血友病A (AHA) 是一种罕见的自身免疫性出血障碍,由VIII因子抑制剂引起.
包括SARS-CoV-2在内的感染是AHA的潜在触发因素.
目前正在调查COVID-19疫苗接种和AHA之间的关联.

研究的目的:

审查有关COVID-19疫苗接种与获得血友病A.之间潜在联系的现有文献.
评估当前关于这个有争议的关联的证据.

主要方法:

18个手稿的系统审查,包括2个案例系列和16个案例报告.
在SARS-CoV-2感染或接种疫苗后报告的AHA病例的分析.

主要成果:

接种COVID-19疫苗,就像其他疫苗一样,可能会诱发自身免疫反应.
AHA是接种疫苗后罕见的潜在不良事件,但总体风险-益处有利于接种疫苗.
患有并发症的老年人患重症COVID-19和AHA的风险更高.

结论:

接种COVID-19疫苗的好处明显超过了疫苗引起的罕见AHA的风险.
需要进一步的前性研究和注册表来了解疫苗后的AHA.
鉴定疫苗相关AHA的风险因素和标志物至关重要.

关键词:

BNT162b2b2 在线阅读在 COVID-19 疫情中,这种疫苗是CoronaVac.这就是SARS-CoV-2病毒.瓦克塞维里亚是什么意思获得的血友病A 不活化的疫苗.在mRNA疫苗的使用中.mRNA-1273 的意思是疫苗疫苗疫苗疫苗病毒载体疫苗病毒载体疫苗

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