在SARS-CoV-2 BNT162b2 mRNA接种疫苗后,长期持续的增强型细胞因子反应
Georgiana Cabău1, Medeea Badii1,2, Andreea M Mirea1
1Department of Medical Genetics, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Vaccines
|July 27, 2024
概括
mRNA COVID-19 疫苗 (BNT162b2) 可以在髓状细胞中诱导持久的非特异性免疫反应. 这种先天免疫记忆表型在接种疫苗后至少持续八个月.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 分子生物学分子生物学
背景情况:
- 针对COVID-19的mRNA疫苗引起了特定的幽默和细胞免疫力.
- 一些疫苗诱导训练免疫力,增强对各种病原体的保护.
- 训练免疫包括非特异性的先天免疫反应,具有潜在的长期影响.
研究的目的:
- 调查BNT162b2 mRNA疫苗是否会在髓状细胞中诱导持久的非特异性免疫反应.
- 为了评估功能性适应和系统性炎症后,三剂疫苗接种方案.
- 为了确定疫苗诱导的先天免疫记忆的持续时间.
主要方法:
- 使用Olink® Target 96炎症面板分析炎症蛋白质.
- 在用病原体识别受体 (PRR) 连接体刺激后评估ex vivo细胞因子反应.
- 在20名健康个体中评估非特异性系统性炎症和髓状细胞功能变化.
主要成果:
- 在增强剂后观察到一种依赖刺激和细胞因子的先天免疫记忆表型.
- 这种免疫记忆持续了八个月.
- 在八个月的随访期间,没有发现系统性炎症的证据.
结论:
- BNT162b2 mRNA疫苗诱导了髓状细胞中持久的,非特异性的先天免疫记忆.
- 这种疫苗诱导的训练免疫在补充剂后建立,持续至少八个月.
- 观察到的免疫记忆独立于持续的全身炎症发生.
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