相关实验视频
Updated: Jul 2, 2026
09:06
Intra-lymph Node Injection of Biodegradable Polymer Particles
Published on: January 2, 2014
14.5K
通过使用原子层沉积来对延迟释放疫苗进行调节控制的演示
Sky W Brubaker1, Isabella R Walters1, Emily M Hite1
1VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
Vaccines
|July 27, 2024
概括
控制抗原释放的单次注射疫苗提供了一种解决方案,可以改善患者的坚持. 原子层沉积 (ALD) 启用了可调节的疫苗释放动力学,影响了未来疫苗设计的抗体反应.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 通常需要多个疫苗剂量才能完全有效,这导致患者坚持和免疫不完整的挑战.
- 开发具有持续抗原释放的单次注射疫苗是克服粘附障碍的关键策略.
研究的目的:
- 研究使用原子层沉积 (ALD) 来制造具有可调节抗原释放动力学的延迟释放疫苗.
- 为优化疫苗设计,建立体外抗原释放和体内抗体反应之间的相关性.
主要方法:
- 利用原子层沉积 (ALD) 用来覆盖含有抗原的粉末,创建延迟释放的疫苗配方.
- 用于体外和体内研究来评估抗原释放率和相应的抗体免疫反应.
- 多种层厚度可调节抗原释放动力学和免疫反应持续时间.
主要成果:
- 证明通过ALD增加氧化层厚度可以精确控制抗原释放的速度.
- 展示了可调节的抗原释放动力学,将免疫反应从几周延长到几个月.
- 确立了重要的体外-体内相关性,用于预测疫苗的性能.
结论:
- ALD是一种可行的技术,用于设计延迟释放疫苗,可预测的抗原输送.
- 对抗原释放动力学的可调控控制为提高疫苗的坚持性和有效性提供了一个有希望的方法.
- 这些发现有可能对未来的一次性疫苗的设计产生重大影响.
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...