艾滋病毒感染者的疫苗可预防疾病负担
Hady Samaha1, Arda Yigitkanli1, Amal Naji1
1The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University, Decatur, GA 30030, USA.
Vaccines
|July 27, 2024
概括
感染艾滋病毒 (PLH) 的人对疫苗的反应较弱,增加了他们患疫苗可预防疾病 (VPD) 的风险. 改进的公共卫生策略对于提高这一弱势群体的疫苗接种率至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 疫苗可预防的疾病 (VPD) 对携带艾滋病毒的人 (PLH) 构成重大健康风险.
- 与普通人群相比,PLH对接种疫苗的免疫反应减少,导致血清转化率降低,疫苗疗效降低.
- 这种免疫损害增加了PLH中对VPD的易感性.
研究的目的:
- 审查艾滋病毒感染者 (PLH) 接种疫苗的挑战.
- 为了突出PLH中低于最佳的疫苗吸收,尽管修改了指南.
- 强调需要针对PLH进行有针对性的公共卫生干预.
主要方法:
- 对艾滋病毒感染者 (PLH) 疫苗反应的文献综述.
- 对现有的疫苗接种指南和PLH的吸收数据的分析.
- 在PLH人群中识别疫苗接种障碍.
主要成果:
- 艾滋病毒感染者 (PLH) 对疫苗的免疫反应延迟和减弱.
- 在PLH中,疫苗的有效性和耐久性下降,增加了疫苗可预防疾病 (VPD) 的风险.
- 尽管有量身定制的指导方针,PLH中接种疫苗的比例仍然不足,这表明存在持续的障碍.
结论:
- 由于疫苗反应受损,艾滋病毒感染者 (PLH) 仍然面临疫苗可预防疾病 (VPD) 的风险增加.
- 目前的疫苗接种策略需要加强,有针对性的公共卫生措施对于改善PLH疫苗接种是必不可少的.
- 需要进一步研究和实施量身定制的干预措施,以解决PLH中VPD的公共卫生问题.
更多相关视频
相关概念视频
Pulmonary Tuberculosis I
228
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
228
Sexually Transmitted Infections
292
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
292
Immunodeficiency Diseases
929
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
929
Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Vaccinations
44.3K
Overview
44.3K
Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K


