后急性COVID-19疫苗接种综合征 (PACVS) 的临床和诊断特征
Anna Katharina Mundorf1, Amelie Semmler1, Harald Heidecke2
1Central Institute for Clinical Chemistry and Laboratory Diagnostics, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
后急性COVID-19疫苗接种综合征 (PACVS) 呈现慢性疲劳和各种神经,心血管和认知症状. PACVS可能代表一种肌痛性脑脊髓炎/慢性疲劳综合征的形式或一种明显的dysautonomia综合征.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 内分泌学 在内分泌学.
背景情况:
- 后急性COVID-19疫苗接种综合征 (PACVS) 是SARS-CoV-2疫苗接种后的一种罕见慢性疾病.
- PACVS的特点是特定的自身抗体,使其与典型的疫苗接种后反应有所区别.
研究的目的:
- 调查PACVS.的临床特征和表型.
- 确定PACVS与现有的慢性疲劳和dysautonomia综合征之间的关系.
主要方法:
- 对191名被诊断患有PACVS.的人员登记册的分析.
- 使用修改的雅卡德指数进行症状聚类.
- 对ME/CFS和dysautonomia的标准血清标记和诊断标准的评估.
主要成果:
- 超过80%的PACVS患者报告了不适和慢性疲劳.
- 常见的症状集群包括周围神经功能障碍,心血管问题和认知/感官障碍.
- 炎症标志物,甲状腺激素,免疫球蛋白,铁和神经丝的异常被观察到,但不是特定于症状的.
- 131/191名参与者符合ME/CFS和/或dysautonomia的标准; 31/191人不符合这些类别.
结论:
- PACVS表现出复杂的临床表型,与ME/CFS和dysautonomia综合征有显著的重叠.
- PACVS可能是ME/CFS的非典型表现或独特的dysautonomia综合征.
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