辅助,基于蛋白质和基于信使核糖核酸 (mRNA) 的COVID-19疫苗之间的反应性差异
Matthew D Rousculp1, Kelly Hollis2, Ryan Ziemiecki2
1Novavax, Inc., Gaithersburg, MD 20878, USA.
Vaccines
|July 27, 2024
概括
对COVID-19疫苗副作用的担忧是常见的. 一项研究发现,基于蛋白质的Novavax (NVX-CoV2373) 疫苗的反应性事件比mRNA疫苗低.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- COVID-19疫苗的反应性可能会导致对更新疫苗的犹.
- 在初级系列完成后,对反应性进行真实世界的数据对于知情的疫苗选择至关重要.
研究的目的:
- 在现实环境中,比较基于蛋白质的疫苗 (NVX-CoV2373) 与mRNA疫苗 (BNT162b2或mRNA-1273) 的反应性.
- 在接种后48小时内评估所要求的局部和全身不良事件.
主要方法:
- 对2019nCoV-406研究的观察性,特此后分析.
- 包括1130名接受NVX-CoV2373 (n=303) 或mRNA疫苗 (n=827) 强剂量的参与者.
- 倾向性得分调整用于控制混因素.
主要成果:
- 与mRNA疫苗相比,NVX-CoV2373的系统反应性事件 (60.5%对84.3%) 和局部事件 (73.4%对91.7%) 的调整率较低.
- 在NVX-CoV2373接受者中,报告的平均系统性症状 (1.8比3.2) 和局部症状 (1.5比2.4) 较少.
- 与NVX-CoV2373 (33.9%与61.4%) 相比,系统反应性症状≥3的发生率显著降低.
结论:
- 与mRNA疫苗相比,辅助蛋白质NVX-CoV2373疫苗的系统和局部反应性明显较低.
- 这些发现支持NVX-CoV2373作为一种可行的免疫选项,具有可能更有利的副作用概况.
- 减少反应性可能有助于缓解疫苗犹,并改善更新的COVID-19疫苗的采用.
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