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季节性流感疫苗使用不同的输送方法的免疫性和反应性之间的关系

Daniel J Gromer^1,2, Brian D Plikaytis³, Michele P McCullough¹

¹The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University, Decatur, GA 30030, USA.

|July 27, 2024

概括

在成年人中对非活化流感疫苗 (IIV) 的反应性更高可能表明基线免疫力较低. 反应性较强的参与者在接种疫苗后显示抗体标位折叠变化增加.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

疫苗的免疫性和反应性受个人和疫苗因素的影响.
对非活化流感疫苗 (IIV) 的反应性和免疫反应之间的关系需要进一步研究.

研究的目的:

调查假设,在健康成年人中,较高的季节性IIV反应性与增加的抗体标位相关.
通过微针贴片 (MNP) 或肌内注射 (IM) 进行IIV注射后分析反应性和免疫反应之间的关联.

主要方法:

一个随机第一阶段试验的二次分析,涉及三价IIV.
开发复合反应性评分和测量血液凝结抑制 (HAI) 标位.
应用混合模型分析差异和修改的Poisson概括估计方程.

主要成果:

在IM组中,H3N2几何平均标位 (GMT) 与系统性和局部反应性评分相关.
反应分数较高的个体基线H3N2 GMTs较低,但在28日时表现出两倍的标位折叠变化.
较高的局部反应性得分与更高的血清转化概率有关.

结论:

对IM IIV的高反应性可能表明基线低的针对特定疫苗抗原的幽默免疫力.
增加的反应性与更大的抗体标位折叠变化相关,尽管总体反应大小与不太反应的个体相似或低.

关键词:

免疫性免疫性免疫性流感疫苗流感疫苗流感疫苗反应性的反应性.

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