通过真菌介导的生物转化产生桑托胡醇衍生物
Yina Xiao1,2, Yutong Cheng3, Shi Shi3
1College of Life Science and Technology, Wuhan Polytechnic University, Wuhan, China.
Natural product research
|July 27, 2024
概括
使用Mucor真菌进行的ksantohumol生物转化产生了新的衍生物. 一些衍生物对A375和A549癌细胞系表现出有前途的细胞毒性活性,有助于抗癌药物开发.
科学领域:
- 自然产品化学 自然产品化学
- 微生物生物转化 微生物生物转化
- 药理学 药理学 是一个学科.
背景情况:
- 赞托摩尔 (XTH) 是一种来自蜂的先化石,具有显著的制药潜力.
- 探索新型XTH衍生物对于增强其治疗应用至关重要,特别是在瘤学中.
研究的目的:
- 通过微生物模型研究香醇 (XTH) 的生物转化.
- 为了隔离和描述新型的XTH衍生品.
- 评估XTH代谢物对特定癌症细胞系的细胞毒性潜力.
主要方法:
- 使用*Mucor* sp.的真菌介导的Xanthohumol (XTH) 生物转化. 在*体外*微生物模型中.
- 准备分离和净化代谢产物.
- 使用全面的光谱分析 (例如NMR,MS) 阐明新代谢物的结构.
主要成果:
- 确定了两种新的代谢物,即 (2′′R) - 双桑醇B (2) 和桑醇L 4'-O-β-D-葡萄皮化物 (5).
- 另外,还分离并对8种已知代谢物 (3,4,611) 进行了表征.
- 化合物7和9分别对A375和A549癌细胞系表现出显著的细胞毒性活性.
结论:
- 微生物生物转化提供了一个可行的策略,用于产生多种类型的Xanthohumol (XTH) 衍生物.
- 特定代谢物的已确定细胞毒性活动为XTH的优化提供了基础.
- 这项研究有助于开发来自Xanthohumol的潜在抗癌药物.
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