肺癌患者需要住院治疗的免疫相关不良事件:含义和见解
Ayo Falade1, Leyre Zubiri2, Chia-Yun Wu2
1Department of Medicine, Salem Hospital, Salem, MA, United States.
The oncologist
|July 27, 2024
概括
在接受免疫检查点抑制剂 (ICI) 治疗的胸部癌症患者中,因免疫相关不良事件 (irAEs) 住院治疗不常见,但与显著的发病率和死亡率有关. 肺炎是导致入院的最常见的irAE.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胸部恶性瘤 胸部恶性瘤
背景情况:
- 免疫检查点抑制剂 (ICI) 可以引起一系列的毒性.
- 关于胸部恶性瘤患者的免疫相关不良事件 (irAEs) 的住院率和临床过程的数据有限.
研究的目的:
- 研究ICI治疗的晚期胸部恶性瘤患者的入院率和irAEs的临床特征.
主要方法:
- 在2016年2月至2021年6月期间接受ICI治疗的晚期胸部恶性瘤患者的回顾性分析.
- 关于人口统计,临床过程和irAE住院的数据被提取并进行描述性分析.
主要成果:
- 在1312名患者中,有102名患者 (7.7%) 因irrAEs住院,肺炎是最常见的原因 (32.3%).
- 入院的中位时间为64天,36%的人经历了多器官毒性.
- 住院患者患病率显著,在60天内住院死亡率为11.8%,再入院率为25.5%,尽管在85.2%的患者中使用了皮质类固醇.
结论:
- 需要住院治疗的严重irrAEs很少发生,但在胸部恶性瘤患者中导致大量的发病率,死亡率和医疗保健利用率.
- 肺炎是最常见的需要住院护理的irAE,即使在免疫抑制下,它也带有显著的死亡风险.
- 需要加强协作努力,以改善IRE的诊断和管理.
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