低收入和中等收入国家低出生体重的孕产妇炎症和微生物驱动因素
Jonathan Broad1,2,3, Ruairi C Robertson1,2, Ceri Evans1,2,4
1Maternal and Child Health Research Department, Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Paediatrics and international child health
|July 27, 2024
概括
孕产妇感染和炎症导致低出生体重 (LBW),影响婴儿的健康和发育. 在怀孕期间解决这些因素可能会改善分娩结果.
科学领域:
- 周围生理学 周围生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 传染性疾病 传染性疾病
背景情况:
- 低出生体重 (LBW) 影响低收入和中等收入国家的七分之一的婴儿,显著影响短期和长期健康.
- 产前暴露于微生物和炎症因素是导致LBW的潜在因素.
研究的目的:
- 评估导致LBW的炎症性,微生物性或感染性原因的作用,怀孕年龄较小,子宫内生长限制和早产.
- 综合现有关于将孕产妇感染和炎症与不良分娩结果联系起来的机制的文献.
主要方法:
- 在Ovid-Medline,Embase和Cochrane数据库中对相关的英语人类研究进行了全面的文献搜索.
- 纳入标准侧重于已发表的数据,不包括会议摘要和灰色文献.
- 使用叙事综合方法来分析研究结果.
主要成果:
- 局部感染 (例如阴道炎,胎盘感染) 和远部炎症 (例如牙周炎,肠功能障碍) 与早产风险增加和子宫内生长减少有关.
- 疟疾和艾滋病毒等全身性孕产妇感染与LBW有关,可能由慢性炎症和社会经济因素介导.
- 抗微生物预防的总体影响很小,但在高传染病负担的环境中观察到对出生体重的一些积极影响.
结论:
- 孕产妇的炎症和感染过程被确定为LBW的潜在因素,这表明了干预的潜在目标.
- 进一步的研究至关重要,以阐明LBW所涉及的复杂机制和途径,以改善终身健康结果.
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