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在MRI中与病态上升阶段相关的因素cT3a前列腺癌 - 从一个大体积中心进行的回顾性研究
Jonathan Ferguson1, Danny Darlington Carbin2, Wissam Abou Chedid1
1Department of Urology, Royal Surrey County Hospital, Egerton Road, Guildford, UK.
World journal of urology
|July 27, 2024
概括
多参数MRI (mpMRI) 可以预测前列腺癌的升级阶段. 国际泌尿病学学会 (ISUP) 评分,前列腺成像报告和数据系统 (PI-RADS) 评分和瘤覆盖率是cT3a前列腺癌升级的关键预测因素.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 对于pT3a前列腺癌的多参数MRI (mpMRI) 参数,缺乏大型队列研究.
- 确定mpMRI cT3a升级的预测因子对于准确的分期至关重要.
研究的目的:
- 确定与mpMRI cT3a在术后组织病理学确认中升级阶段相关的因素.
- 评估前列腺癌升级阶段的各种临床和成像参数的预测价值.
主要方法:
- 对383名患有cT3a前列腺癌的前后分析,这些患者接受了机器人辅助激进前列腺切除术 (RARP).
- 由专家泌尿放射学家和泌尿组织病理学家对MRI和组织病理学的独立审查.
- 分析年龄,BMI,PSA,ISUP等级,PI-RADS得分,瘤大小,覆盖范围,腺体体重和手术边缘作为pT3a前列腺癌的预测因素.
主要成果:
- 18.0%的病例在手术后升级了阶段.
- 前列腺特异性抗原 (PSA) 水平,PI-RADS得分和ISUP等级与上升阶段积极相关.
- 在ISUP等级≥3,PI-RADS得分≥4,和瘤覆盖率显著预测升级.
- 较高的瘤覆盖率与积极的外科手术边缘相关.
- 囊接触>15毫米与更低的升级可能性有关.
结论:
- 血抗原水平,ISUP等级,PI-RADS得分和瘤覆盖率是cT3a升级的关键预测因素.
- 瘤覆盖率是mpMRI上cT3a升级的一个独特预测因素.
- ISUP等级是最强的预测指标,其次是PI-RADS得分和瘤覆盖率.
- 建议进行多机构研究来验证这些发现.
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