精确治疗人环素诱导的心脏毒性:一个更新的审查
Ziyu Kuang1,2, Yuansha Ge1,2, Luchang Cao1
1Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 10053, China.
Current treatment options in oncology
|July 27, 2024
概括
人环素诱导的心脏毒性 (AIC) 在癌症治疗中构成了重大挑战. 研究正在澄清AIC的情况.
科学领域:
- 心血管毒理学心血管毒理学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 人环素 (ANT) 诱导的心脏毒性 (AIC) 限制了人环素的临床使用,这是化学疗法药物的重要类别.
- 尽管进行了广泛的研究,但AIC的最佳治疗策略仍然难以捉摸,需要对其潜在机制有更深入的了解.
研究的目的:
- 审查涉及AIC的分子途径.
- 系统地讨论AIC的当前和新型预防和治疗策略.
- 提供关于AIC管理的挑战和未来方向的见解.
主要方法:
- 对有助于AIC的分子通路的文献综述.
- 对现有和新兴的治疗干预措施进行系统的讨论.
- 分析AIC预防和治疗当前的困境和挑战.
主要成果:
- 关键的分子通路包括氧化应激,拓聚酶活性,炎症,心脏原生细胞损伤,表观遗传变化和氨酸- ангиотензин- 氨酸系统 (RAAS) 失调.
- 预防和治疗策略包括剂量修改,药物输送改变,抗氧化剂,德克斯拉松,他类药物,RAAS抑制剂,低血糖药物,miRNA,植物化学物质和干细胞疗法.
- 在有效预防和治疗AIC方面仍然存在重大挑战,这凸显了继续研究的必要性.
结论:
- 了解AIC的多面分子基础对于开发有效干预措施至关重要.
- 包括干细胞和植物化学品在内的既定和新型疗法的组合显示出对管理AIC的希望.
- 解决AIC管理中的当前困境需要进一步研究基于病原性疗法的方法.
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