相关实验视频
Updated: Jun 18, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
系统管理高级上皮层癌的系统管理
1Division of Medical Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, 84112, USA. jeffery.russell@hci.utah.edu.
上皮层癌 (ACC) 治疗仍然具有挑战性. 目前的选择包括EDP化疗加上mitotane,免疫疗法和临床试验为晚期疾病提供未来的希望.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 癌症研究 癌症研究
背景情况:
- 上皮上腺癌 (ACC) 是一种罕见的,侵袭性的内分泌恶性瘤,预后不佳.
- 对局部晚期ACC的最佳新辅助和辅助疗法进行辩论,其复发率和转移率很高.
- 有限的全身性药物已经显示出有效性,只有米托坦在美国被批准用于ACC.
研究的目的:
- 审查当前对上腺皮层癌的全身治疗选择.
- 讨论用于ACC治疗的新药和正在进行的临床试验.
- 为一线和二线全身疗法提供基于证据的建议.
主要方法:
- 综述来自多项研究的数据,评估ACC中的系统性药物.
- 分析当前的全身疗法组合.
- 讨论ACC正在进行的临床试验.
主要成果:
- EDP化疗加上米托坦是推的第一线治疗先进的,不可切除的或转移的ACC.
- 第二线治疗考虑因素包括PD(L) 1抑制剂与TKI/VEGF抑制剂相结合或组合免疫疗法 (PD1/CTLA-4).
- 临床试验是首选的,如果可用于ACC的所有阶段.
结论:
- 对ACC的全身治疗正在发展,化疗和向药物显示出有前途.
- 免疫疗法组合代表了二线治疗的潜在进步.
- 参与临床试验对于推进ACC治疗和改善生存结果至关重要.
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