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基因预测血管蛋白和内动脉瘤风险:孟德尔的随机化研究

Xinyang Yan¹, Jiachen Wang², Yunfei Zhou¹

¹Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.

Molecular neurobiology

|July 27, 2024

概括

低血清TNFSF14水平可能会增加内动脉瘤破裂的风险. 几种血管蛋白与内动脉瘤的风险有关,包括HBEGF,MCP-1,IL-6,CX3CL1和AgRP.

科学领域:

遗传学和心血管研究
神经科学和神经病学神经科学和神经病学

背景情况:

血管蛋白 (VPs) 和内动脉瘤 (IAs) 之间的确切关系仍然不完全理解.
调查这些联系对于理解IA病原体和确定潜在的治疗点至关重要.

研究的目的:

探索血管蛋白对使用孟德尔随机化的内动脉瘤风险的因果关系.
为了确定与动脉瘤下关节出血 (aSAH) 和未破裂的内动脉瘤 (uIA) 相关的特定VP.

主要方法:

使用两个样本的门德尔随机化 (MR) 分析,对aSAH和uIA的大型欧洲祖先数据集进行分析.
进行了单变量和多变量MR (MVMR) 分析,以评估90VP与IA风险之间的关联.
调整了潜在的混因素,包括吸烟,酒精消费,缩血压和MVMR中的BMI.

主要成果:

TNFSF14与aSAH显示出显著的反向关联,这表明它具有保护作用.
IL-16和AgRP与aSAH风险积极相关.
HBEGF,MCP-1和CX3CL1与uIA风险相关,而IL-6也与整体IA风险有关.

结论:

低血清TNFSF14水平可能代表内动脉瘤破裂的潜在风险因素.
一些VP,包括HBEGF,MCP-1,IL-6,CX3CL1和AgRP,与发展IA的风险有关.

关键词:

动脉瘤下arachnoid出血动脉瘤下arachnoid出血动脉瘤下arachnoid出血内动脉瘤内动脉瘤门德尔的随机化多变量MR是多变量的MR.瘤亡因子连接剂超级家族成员14 血管蛋白是血管中的蛋白质.

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