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Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
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在植物性食补充剂成分参考材料中确定有毒元素

Jennifer Fong Sam1, Adam J Kuszak2, Patrick J Gray1

  • 1Food and Drug Administration, Chemical Contaminants Branch, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA.

Journal of AOAC International
|July 27, 2024
PubMed
概括

这项研究确定了植物性食补充剂参考材料中的有毒元素含量. 结果为准确分析补充剂提供了关键数据,通过识别,,和等潜在污染物,确保消费者安全.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...