揭开农药与糖尿病的联系:一个整合孟德尔随机化分析的案例和队列研究,重点关注身体活动的减轻效应
Dandan Wei1, Jiayu Shi1, Zhiwei Chen1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
农药暴露,无论是单独的还是联合的,都会增加中国农村人口中患有禁食葡萄糖受损的2型糖尿病的风险. 身体活动可以减轻这种风险.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 内分泌学 在内分泌学.
背景情况:
- 在中国农村人口中,农药混合物与2型糖尿病 (T2DM) 之间的纵向和因果关系的证据有限.
- 身体活动 (PA) 在这些关联中的改变作用仍然不清楚.
研究的目的:
- 调查农药混合物与T2DM发病率之间的纵向和因果关系.
- 为了确定体力活动是否改变这些协会在中国农村队列.
主要方法:
- 一项涉及925名正常葡萄糖和925名快食葡萄糖受损 (IFG) 个体的病例和队列研究.
- 在基线51种农药的定量化,使用后勤回归,量子式g计算和贝叶斯核机器回归 (BKMR) 进行分析.
- 孟德尔随机化 (MR) 分析被用来评估因果关系.
主要成果:
- 高水平的特定农药 (异,马拉,德尔塔米特林) 和农药混合物 (OCP,OP,除草剂,铁) 与IFG患者中T2DM发病率的增加有关.
- BKMR和MR分析支持农药混合物暴露与T2DM风险之间的积极关联.
- 低水平的体力活动增加了IFG患者与农药暴露相关的T2DM风险.
结论:
- 单个和联合的农药暴露显著增加了IFG患者的T2DM发病率.
- 门德尔的随机分析证实了农药暴露与T2DM风险之间的因果关系.
- 发现较高的体力活动水平可以减轻暴露在农药中的糖尿病原性影响.
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