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在二维气色谱中使用它们的保留行为在母乳中选具有生物积累潜力的化合物

Yingxin Zhang¹, Lirong Gao², Qiaofeng Ai¹

¹State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Environment international

|July 27, 2024

概括

一种新方法在中国母乳中发现了1286种生物积累化合物,其中27种是首次发现的. 包括酸盐在内的13种化合物具有更高的健康风险,有助于对人类暴露的评估.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
人类健康风险评估

背景情况:

母乳中的新出现的污染物对人类健康构成风险.
在复杂样品中识别关键的危险化合物是一项挑战.

研究的目的:

开发一种选母乳中生物累积化合物的方法.
根据潜在的健康风险优先考虑化合物.

主要方法:

利用气色谱-气色谱 (GC×GC) 保留行为来映射分区属性.
分析了来自中国七个省份的20个母乳样本.
应用了考虑度,频率和毒性影响的毒理优先指数.

主要成果:

选了3000多种化合物,选择了1286种具有生物积累潜力的化合物.
鉴定和量化了62种化合物,包括27种新的母乳污染物.
在显著高度下发现了酸盐可塑剂和性抗氧化剂.

结论:

开发的方法有效地选生物累积化合物.
13种优先考虑的化合物,包括特定的酸盐和,表明健康风险更高.
这项研究对于评估人类接触有机化合物的风险至关重要.

关键词:

生物积累潜力可能存在.母乳是母乳中的一种.GC×GC 是一个GC.危害健康的风险健康风险分区属性分区属性确定优先级确定优先级

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