在严重的COVID-19患者中,免疫炎症和器官功能障碍标志物
Najat Jabbar Ahmed1, Zahra A Amin2, Ramiar Kamal Kheder3
1Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil 44001, Iraq.
Cytokine
|July 27, 2024
概括
SARS-CoV-2 感染可能导致严重并发症,特别是在老年人和患有慢性疾病的人群中. 这项研究调查了COVID-19患者的重要生物标志物,揭示了与健康对照人群相比显著的差异.
科学领域:
- 传染性疾病 传染性疾病
- 临床生物化学 临床生物化学
- 免疫学 免疫学 免疫学
背景情况:
- SARS-CoV-2 感染呈现了一系列疾病,从轻微的呼吸道症状到需要医疗干预的严重疾病.
- 老年人和患有先前存在的慢性疾病的人面临更高的COVID-19严重并发症风险.
- 细胞因子风暴是一种已知的高炎症反应,与严重的COVID-19相关.
研究的目的:
- 研究SARS-CoV-2感染对重要器官生物标记物的影响.
- 为了比较COVID-19患者和对照组之间的生物标志物水平.
- 通过生物标志物分析评估SARS-CoV-2和细胞因子风暴之间的关联.
主要方法:
- 从已确认的SARS-CoV-2感染个体和对照组收集了血清和全血样本.
- 实时PCR用于SARS-CoV-2的确认.
- 实验室调查使用Cobas 6000自动化系统进行.
主要成果:
- 在患者和对照人群之间观察到介乐金-6 (IL-6),前素,C反应蛋白 (CRP),氨酸转胺酶 (ALT) 和酸转胺酶 (AST) 水平的显著差异.
- 在COVID-19患者中观察到IL-6,前素,CRP,ALT和AST的水平升高.
- 其他生物标志物包括D-Dimer,前血时间 (PT),部分血栓形成时间 (PTT),乳酸脱酶 (LDH),费里丁,白细胞计数 (WBC),淋巴细胞计数和肌素也显示出显著的变化.
结论:
- SARS-CoV-2 感染显著影响重要器官的生物标志物.
- 观察到的生物标志物变化表明,细胞因子风暴对多个器官的影响.
- 生物标志物调查为严重的COVID-19的病理生理学提供了关键的见解.
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