相关实验视频

Updated: Jun 18, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.3K

对于高度选择性的CK2α向化学链接的合成和评估

Francesco A Greco1, Andreas Krämer2, Laurenz Wahl1

  • 1Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt Am Main, Germany; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt Am Main, Germany.

European journal of medicinal chemistry
|July 27, 2024
PubMed
概括

研究人员通过结合全性和ATP竞争性策略开发了新型,高度选择性的氨酸激酶-2 (CK2) 抑制剂. 这种基于结构的设计提供了一种针对CK2的新方法,CK2是细胞功能的关键调节器.

关键词:
艾洛斯特抑制剂 艾洛斯特抑制剂凯赛因激酶 2 2 酶抑制器结合模式 抑制器结合模式激酶抑制剂选择性的选择性有理性的抑制剂设计.

更多相关视频

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach11:11

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

7.4K
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

4.1K

相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
4.8K