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Updated: Jun 18, 2025

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
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CDK8/19抑制剂通过STAT6和p38 MAPK激活增强巨细胞中阿尔金酶-1的表达

Natsumi Mizuno1, Saki Shiga1, Yoshiyuki Tanaka1

  • 1Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Kanazawa 1757, Tobetsu, Ishikari, 061-0293, Japan.

European journal of pharmacology
|July 27, 2024
PubMed
概括

使用BRD6989的环林依赖激酶 (CDK) 8/19抑制,增加了巨细胞中的阿尔金酶-1表达. 这一过程涉及激活STAT6和p38 MAPK,促进抗炎M2巨细胞的产生.

关键词:
阿尔金纳-1 的作用.循环素依赖的蛋白质激酶.介质蛋白-4 介质蛋白-4 介质蛋白-4巨细胞是一个巨细胞.p38 中原激活蛋白酶激酶的作用.

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