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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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相关实验视频

Updated: Jun 18, 2025

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
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循环T毛囊辅助细胞的年龄相关下降与COVID-19的老年患者的疾病严重程度相关.

Yihan Wang1, Qiu Wang2, Furong He1

  • 1Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University, No. 22 Qixiangtai Road, Tianjin 300070, China.

Clinical immunology (Orlando, Fla.)
|July 27, 2024
PubMed
概括

衰老显著增加COVID-19的严重程度通过耗尽关键的T毛囊辅助细胞 (Tfh) 和T毛囊调节细胞 (Tfr). 疫苗接种使这些细胞再生,增强抗体的产生,改善老年人的结果.

关键词:
衰老的衰老 衰老的衰老在 COVID-19 疫情中,循环的T毛囊辅助细胞.老年患者的患者.淋巴细胞减少症 (Lymphopenia) 是一种接种疫苗 接种疫苗

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科学领域:

  • 免疫学 免疫学 免疫学
  • 老年学是一门学科.
  • 病毒学 病毒学

背景情况:

  • 老龄化是严重的COVID-19的主要风险因素之一.
  • 特定的T细胞子集随着年龄的增长而变化,以及它们在COVID-19严重性中的作用需要澄清.

研究的目的:

  • 为了研究老年COVID-19患者的年龄依赖的T细胞子集变化.
  • 评估这些子集对疾病严重程度和抗体产生的影响.
  • 评估SARS-CoV-2疫苗接种对这些免疫细胞和反应的影响.

主要方法:

  • 招募了57名老年COVID-19患者和27名康复的捐赠者.
  • 评估了COVID-19严重程度范围内的适应性免疫力.
  • 分析了循环T毛囊调节细胞 (cTfh) 的子集和循环T毛囊调节细胞 (cTfr) 的比例.

主要成果:

  • 老年患者表现出与年龄相关的CD4+ T淋巴缺血和各种cTfh子集的丧失 (cTfh-em,cTfh-cm,cTfh1,cTfh2,cTfh17) 和cTfr.
  • 这些cTfh和cTfr子集与COVID-19的严重程度相关.
  • 疫苗接种改善了cTfh-cm,cTfh2,cTfr比例,并增强了中和抗体 (NAb) 的产生.

结论:

  • 在cTfh子集和cTfr中依赖年龄的缺陷会损害NAb的产生,在老年人中恶化COVID-19的严重程度.
  • 接种SARS-CoV-2疫苗会使cTfh和cTfr细胞再生,从而加剧NAb反应并减轻疾病的严重程度.