一个以蚊子鼻为灵感的曲面微针贴片用于眼科区域麻醉
Xuequan Liu1, Xuequan Sun2, Hongyu Zhu3
1Qingdao Key Laboratory of Materials for Tissue Repair and Rehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, School of Rehabilitation Science and Engineering, Qingdao 266113, China; Department of Anesthesiology, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, China.
Journal of advanced research
|July 27, 2024
概括
一种新型的微针贴片提供利多卡因,用于快速,无痛的局部麻醉,灵感来自蚊子鼻. 这种最少的侵入性方法克服了传统的输送限制,为眼科治疗提供了新的可能性.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 眼科医生 眼科 眼科
背景情况:
- 局部麻醉对于疼痛管理至关重要,但眼科区域麻醉的传统输送方法有局限性.
- 这些局限性包括疼痛,需要熟练的专业人员,以及药物缓慢扩散.
研究的目的:
- 为眼科区域麻醉中局部麻醉剂开发一种替代性的,最少侵入性的药物输送系统.
- 为了创建一个快速溶解的微针 (MNs) 贴片,以有效和无痛的利多卡因输送.
主要方法:
- 使用聚乙烯 (PVP) 和氨酸 (HA) 开发了一种快速溶解的曲面微针 (MNs) 补丁.
- 该贴片的灵感来自蚊子的鼻,其中含有25个装有利多卡因的微针 (Lido) (MNs@Lido).
- 在皮肤和眼球模型上评估了细胞相容性,角膜透,自我愈合特性和止痛作用.
主要成果:
- MNs@Lido贴片表现出良好的细胞兼容性和足够的刚性,可以在没有受伤的情况下穿透角膜.
- 由微针创建的角膜针孔通道在24小时内完全自我愈合.
- 在脚皮肤和眼球上观察到有效的止痛作用,麻醉至少持续30分钟.
结论:
- 这种以蚊子鼻为灵感的微针贴片为局部麻醉提供了一种快速而无痛的方法.
- 这种创新的输送系统克服了传统方法的局限性,为眼科疾病提供了新的治疗途径.
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