Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Lenz's Law01:15

Lenz's Law

The direction in which the induced emf drives the current around a wire loop can be found through the negative sign. However, it is usually easier to determine this direction with Lenz's law, named in honor of its discoverer, Heinrich Lenz (1804–1865). Lenz's law states that the direction of the induced emf drives the current around a wire loop always to oppose the change in magnetic flux that causes the emf.
If a bar magnet is moved toward a coil such that the magnetic flux through the coil...
Indeterminate Structure01:18

Indeterminate Structure

Indeterminate structures refer to structures where internal forces and reactions cannot be determined using only the equations of static equilibrium.  Indeterminate structures have more unknown forces and reaction forces than equations of static equilibrium that can be used to determine them. Indeterminate structures are often used in engineering to create complex, efficient, and aesthetically pleasing structures. There are various types of indeterminate structures used in engineering and some...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Structural Properties and Dimensions of Lumber01:21

Structural Properties and Dimensions of Lumber

Wood's structural properties derive from fibers aligned along the tree's length, contributing significantly to its mechanical strength. Wood exhibits up to twenty times greater tensile strength along these fibers compared to across them, and generally shows better performance under compression than tension. The length of fibers varies, with hardwoods having fibers around one twenty-fifth inch long and softwoods ranging from one-eighth to one-third inch.
The strength characteristics of wood are...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A perspective on the apparent pKa of ionizable lipids in mRNA-LNPs.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Enhancing RNA encapsulation quantification in lipid nanoparticles: Sustainable alternatives to Triton X-100 in the RiboGreen assay.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2024
Same author

Technical challenges of studying the impact of plasma components on the efficacy of lipid nanoparticles for vaccine and therapeutic applications.

Nature communications·2024
Same author

Tuning the double lipidation of salmon calcitonin to introduce a pore-like membrane translocation mechanism.

Journal of colloid and interface science·2024
Same author

Deciphering the monocyte-targeting mechanisms of PEGylated cationic liposomes by investigating the biomolecular corona.

International journal of pharmaceutics·2024
Same author

Lipid nanoparticle-based strategies for extrahepatic delivery of nucleic acid therapies - challenges and opportunities.

Journal of controlled release : official journal of the Controlled Release Society·2024

相关实验视频

Updated: May 30, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.6K

一个关于空白和空的LNP结构的观点

Jens B Simonsen1

  • 1Jbsimonsen Consult, Grønnevej 160, 2830 Virum, Denmark.

Journal of controlled release : official journal of the Controlled Release Society
|July 27, 2024
PubMed
概括
此摘要是机器生成的。

用于mRNA输送的脂质纳米粒子 (LNP) 可以包含"泡"和空粒子. 本视角探讨了它们对安全性和疗效的影响,并提出了研究和量化方法,以改善LNP药物开发.

关键词:
布雷布布雷布布布布布布布布布布布布布布布布布布布布布布布这是空的,空的.在LNP中使用LNP.脂质纳米颗粒的使用方法量化是指量化的结构 结构 结构 结构

更多相关视频

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

6.9K
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
00:11

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

23.7K

相关实验视频

Last Updated: May 30, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

9.6K
Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

6.9K
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
00:11

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

23.7K

科学领域:

  • 生物技术是生物技术.
  • 药物输送系统 药物输送系统
  • 纳米医学是一种纳米医学.

背景情况:

  • 脂质纳米颗粒 (LNP) 是FDA批准的mRNA输送.
  • 了解LNP异质性对于优化其使用至关重要.
  • 布勒布和空的LNP是常见的结构和组成变化.

研究的目的:

  • 讨论blebs和空的LNP的存在和影响.
  • 审查关于LNP结构异质性的现有文献.
  • 提出研究和量化这些特征的新策略.

主要方法:

  • 关于LNP结构和组成异质性的关键文章的文献综述.
  • 分析关于blebs和空LNP属性的相互矛盾观点.
  • 讨论当前和新的量化方法.

主要成果:

  • 关于blebs和空的LNP的影响存在相互矛盾的观点.
  • 关于安全性和疗效影响的系统研究有限.
  • 讨论了当前的研究和质量控制方法来处理这些异质性.

结论:

  • 需要进一步的研究,以了解斑块和空的LNP的作用.
  • 研究这些特征的新策略可以增强LNP的发展.
  • 接受,利用或减轻这些异质性可能会改善基于LNP的药物产品.