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暴露于基于草甘的除草剂的Ewe羔羊的卵巢储备发生变化

Ramiro Alarcón¹, Ana Laura Alegre¹, Oscar Rivera²

¹Instituto de Salud y Ambiente del Litoral (ISAL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Bioquímica y Ciencias Biológicas Universidad Nacional del Litoral, Santa Fe, Argentina.

|July 27, 2024

概括

新生儿暴露于基于草甘的除草剂 (GBH) 在母羊羔通过破坏关键的卵泡发育分子和干扰淋巴激素作用来减少卵巢储备. 这表明,这可能会对女性生殖功能产生长期影响.

科学领域:

生殖毒理学生殖毒理学
内分泌学在内分泌学.
发展生物学发展生物学

背景情况:

基于草甘的除草剂 (GBHs) 被认为是影响女性生殖系统的内分泌干扰剂.
新生儿接触环境毒素可能对生殖健康产生持久影响.

研究的目的:

为了研究新生儿低剂量GBH暴露对母羊羔卵巢卵泡储量的影响.
评估 GBH 暴露对猪毛囊刺激激素 (pFSH) 刺激反应的影响.

主要方法:

雌羊羔从出生后的第1天到第14天暴露于GBH剂量 (1mg/kg/天) 或载体.
一些羊羔在出生后41日至43天之间接受了pFSH刺激.
卵巢组织分析了卵泡类型和基因表达 (RT-PCR) 的关键生殖激素和受体.

主要成果:

暴露于GBH显著降低了雌激素受体α,孕激素受体,ACVRII和BMP15.15的mRNA水平.
pFSH刺激导致对照羔羊的预期基因表达变化,但在暴露于GBH的羔羊中却被削弱.
暴露于GBH减少了原始和毛囊中的抗米勒尔激素表达和骨形态遗传蛋白4 .

结论:

新生儿暴露于GBH会破坏卵泡发育的关键分子,并损害卵巢对淋巴体刺激的反应.
暴露于GBH会导致母羊羔的卵巢储量下降.
需要进一步的研究来确定对成年卵巢功能和超排卵反应的长期影响.

关键词:

动物生产动物生产环境污染环境污染生育能力生育能力生育能力草甘是一种天然的草甘.抗穆勒尔激素的激素是反穆勒尔的激素.

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