可穿戴的固态微提取样本,用于增强在人类耳朵中的挥发性分析物的检测
Wenzheng Mo1, Lei Li1, Bi-Cheng Yang2
1College of Environment and Climate, Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air Pollution, Jinan University, Guangzhou, 510632, China.
Analytica chimica acta
|July 27, 2024
概括
一个新的可穿戴设备在耳罩中使用固相微提取来非侵入性地检测耳朵分子. 这种方法提高了对代谢物和暴露的检测,为健康监测和诊断提供了潜力.
科学领域:
- 分析化学 分析化学
- 生物医学工程 生物医学工程
- 环境科学 环境科学
背景情况:
- 由于传统诊断方法的局限性,分子级耳朵检查很困难.
- 需要用于耳部分析的非侵入性,敏感和方便的分析技术.
研究的目的:
- 开发一种用于人类耳朵中进行非侵入性分子检测的新型可穿戴设备.
- 建立一种用于增强检测耳朵中微量分析物的方法.
主要方法:
- 开发一种可穿戴的采样装置,将固相微提取 (SPME) 纤维集成到改性耳罩 (SPME-in-earmuffs) 中.
- 使用气相色谱-质谱法 (GC-MS) 来识别和量化提取的分析物.
- 证明了对挥发性代谢物,环境暴露和治疗药物在耳朵中的增强检测.
主要成果:
- 耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩式耳罩
- 该方法在检测耳部药物方面表现出色的分析性能,检测限值低 (0.005-0.021 ng/mL) 和量化限值低 (0.018-0.071 ng/mL).
- 实现了高线性 (R2>0.99),良好的精度 (84.43-150.18%) 和可接受的精度 (RSDs 13.19%-21.40%).
结论:
- 这项研究介绍了第一个可穿戴的微提取方法,用于检测人类耳朵中的挥发性化合物.
- 该设备可以在耳罩外内进行头部空间SPME采样,从而促进非侵入性监测.
- 该方法显示出在人类健康,疾病诊断和体育科学等领域有很大的应用潜力.
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Sampling materials are classified into three main types: solid, liquid, and gas.
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Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
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