药物耐药性肺结核患者药物不良反应
Shraddha Tewari1, Rushi Patel1, Karmay Shah1
1Gujarat Cancer Society Medical College and Research Center, Ahmedabad, Gujarat, India.
The Indian journal of tuberculosis
|July 27, 2024
概括
药物不良反应 (ADR) 在耐药结核病 (DR-TB) 患者中常见,这些患者使用口服或注射疗法治疗. 大多数反应发生在30天内,在许多情况下需要药物停用,但没有观察到死亡.
科学领域:
- 医学研究 医学研究
- 临床药理学 临床药理学
- 结核病治疗方法 结核病治疗方法
背景情况:
- 耐药结核病 (DR-TB) 需要复杂的治疗方案.
- 药物不良反应 (ADR) 是DR-TB管理的一个重大挑战.
- 了解ADR模式对于优化患者护理至关重要.
研究的目的:
- 调查DR-TB患者中ADR的发生率和特征.
- 识别最常见的ADR及其时间.
- 评估DR-TB患者对ADRs的管理和结果.
主要方法:
- 从2019-2022年进行的回顾性研究.
- 参与了275名在各种DR-TB疗程中的患者.
- 收集关于副作用,住院和治疗修改的数据.
主要成果:
- 在275名患者中,有55名患者经历了副作用.
- 20-40岁的年龄组受影响最大.
- 最多的副作用发生在治疗的前30天内.
- 在41.81%的病例中,需要戒药.
- 32.7%的人要求永久停止使用违规药物.
- 32.7%需要住院治疗,其中一部分需要ICU护理.
结论:
- 抗药性结核病患者经常出现ADR,特别是在治疗初期.
- 管理通常涉及药物戒断或永久停药.
- 尽管有副作用,但在研究期间没有记录死亡率.
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