在耐药结核病-A病例系列中,线索利德诱导的有毒视神经病变
Siddharth Vallabhaneni1, Teena Mariet Mendonca2, Rajesh R Nayak2
1Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.
The Indian journal of tuberculosis
|July 27, 2024
概括
在印度用于治疗耐药结核病的线索利德可以引起有毒的视神经病变,导致视力丧失. 早期戒药可以恢复视力,强调需要对这种严重并发症进行临床意识.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 莱涅佐利德是治疗多耐药结核病 (MDR-TB) 和广泛耐药结核病 (XDR-TB) 的关键抗生素,特别是在印度等发展中国家.
- 长期使用Linezolid与有毒的视神经病变有关,这种疾病的特征是渐进的双边视力丧失.
研究的目的:
- 报告和分析使用Linezolid进行抗结核治疗的患者中有毒视神经病变的病例.
- 强调识别Linezolid诱导的视觉并发症的重要性.
主要方法:
- 一系列病例报告了三名患者出现突然,无痛,渐进的视力模糊.
- 临床检查和诊断有毒的视神经病变,证实是由Linezolid引起的.
- 在停止使用Linezolid后,视力恢复的监测.
主要成果:
- 在接受抗结核治疗的三名患者中,出现了因线索利德而导致的有毒视神经病变.
- 两名患者在停止使用Linezolid后经历了完全的视力恢复.
- 一名患者由于二次视力缩而显示出最小的视力改善.
结论:
- 利尼佐利德可以引起危及视力的有毒视神经病变,即使在接受结核病治疗的患者中也是如此.
- 临床医生和医疗保健工作者之间的意识对于早期检测和管理Linezolid诱导的视力障碍至关重要.
- 立即停止使用Linezolid对于视力恢复至关重要.
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