两个病例表明Tropheryma whipplei和肺边缘区域淋巴瘤之间的关联
J D Haslbauer1, C Wiegand2, B Hamelin2
1Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Infectious agents and cancer
|July 27, 2024
概括
托弗里玛·惠普莱肺部感染可能引发肺边缘区域淋巴瘤 (PMZL). 阿克罗巴克特菌 (Achromobacter xylosoxidans) 在肺部很常见,但不太可能导致PMZL.
科学领域:
- 肺部瘤学 肺部瘤学
- 传染病 传染病 传染病
- 微生物学 微生物学
背景情况:
- 粘膜关联淋巴组织的边缘区域淋巴瘤 (MALT的MZL) 是与慢性炎症相关的惰性B细胞瘤.
- 肺部MZL (PMZL) 的病因尚不清楚,此前Achromobacter xylosoxidans被认为是潜在的原因.
- 慢性感染或自身免疫性疾病都与MZL的发病有关.
研究的目的:
- 调查Tropheryma whipplei在肺部MZL (PMZL) 的发展中的作用.
- 为了比较T. whipplei和Achromobacter xylosoxidans在PMZL患者与对照者的患病率.
主要方法:
- 使用PCR和元基因下一代测序 (mNGS) 识别了与Tropheryma whipplei相关的PMZL指数病例.
- 追溯分析了22名PMZL患者的肺组织,并使用PCR和mNGS对T. whipplei进行控制.
- 在181个肺样本中对T. whipplei和A. xylosoxidans进行了系统的mNGS搜索.
主要成果:
- 在两个PMZL病例中检测到T. whipplei;感染之前的淋巴瘤诊断.
- 与T. whipplei相关的PMZL病例只有很少的突变,这表明细菌可能驱动淋巴发育.
- 在非PMZL肺组织中经常检测到A. xylosoxidans (> 50%),这表明它是正常肺微生物组的一部分.
结论:
- 肺部被T. whipplei殖民可能会起到PMZL发展的触发作用.
- 需要对更大的队列进行进一步的研究,以确认T. whipplei在PMZL中的作用.
- 肺组织中A. xylosoxidans的高患病率表明,它不太可能是PMZL的主要驱动因素.
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