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Updated: Jun 18, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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通过MnO2纳米粒子激活的STING通路重新分离中性粒细胞可以增强沙门氏菌介导的瘤免疫疗法

Shan Lu1, Ze Mi2, Peng Liu3

  • 1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China.

Journal of nanobiotechnology
|July 27, 2024
PubMed
概括

工程沙门氏菌免疫疗法受到中性粒细胞的限制. 将沙门氏菌与MnO2纳米颗粒结合起来,可以使中性粒细胞再极化,增强抗瘤免疫力和生存率.

关键词:
免疫治疗是一种免疫疗法.金属氧化物 是一种金属氧化物.微生物疗法是一种微生物疗法.纳米医学是一种纳米医学.瘤治疗疗法 瘤治疗

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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