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建立基于影响免疫微环境的灭相关基因的前列腺癌的诺莫格拉姆预测
Chundong Ji1, Sandeep Shrestha1, Farra Aidah Jumuddin1
1Department of Histology and Pathology, Faculty of Medicine, Lincoln University College, Malaysia.
Asian Pacific journal of cancer prevention : APJCP
|July 28, 2024
概括
与热相关的基因 (CASP3,PLCG1,GSDMB,GPX4) 显著影响前列腺癌免疫微环境. 这些基因可以作为预测患者预后和生存结果的关键生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 前列腺癌是一种常见的恶性瘤,预后不佳.
- 热,一种编程细胞死亡的形式,影响瘤的免疫微环境.
- 在前列腺癌的预后中,与热致死相关的基因的特定作用仍未得到充分研究.
研究的目的:
- 为了研究与火死相关的基因与前列腺癌中的免疫微环境之间的关联.
- 为了确定可预测前列腺癌预后的灭相关基因.
- 开发前列腺癌存活率的预测模型.
主要方法:
- 对前列腺癌组织与正常组织中33个与细胞死亡相关的基因的差异表达分析.
- 不同表达基因的功能丰富分析.
- 单变和LASSO考克斯回归以确定预后性热与相关的基因.
- 免疫相关性分析和名录构造用于生存预测.
主要成果:
- 鉴定了17个差异表达的灭与相关的基因,与前列腺癌细胞灭有关.
- 四个基因 (CASP3,PLCG1,GSDMB,GPX4) 与前列腺癌预后有显著联系.
- CASP3,PLCG1和GSDMB的表达与免疫细胞透有正相关,而GPX4与免疫细胞透有负相关.
- 一个包含格里森分数,T阶段和这四个基因的诺莫图准确地预测了患者的存活时间.
结论:
- CASP3,PLCG1,GSDMB和GPX4是前列腺癌中关键的细胞死亡相关基因.
- 这些基因在调节瘤免疫微环境方面发挥着关键作用.
- 已识别的与火死相关的基因作为前列腺癌预后的有价值的预测生物标志物.
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