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基于血管性脂质的药物输送系统 (PhytoSolve) 用于在动物模型中治疗薄的子宫内膜

Ladan Haghighi¹, Marziyeh Ajdary¹, Azam Govahi¹

¹Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.

|July 28, 2024

概括

一种基于S75脂质的新型PhytoSolve药物递送系统,载有血管内皮生长因子 (VEGF),通过促进血管形成和增加子宫内膜厚度,有效地治疗薄子宫内膜.

科学领域:

生物医学工程生物医学工程
药物输送系统药物输送系统
生殖医学生殖医学

背景情况:

薄的子宫内膜,往往是由于减少的血管内皮生长因子 (VEGF) 的血管生长受损引起的,提出了治疗挑战.
血管新生诱导是治疗子宫内膜薄的潜在策略.

研究的目的:

开发和评估一种新的药物输送系统,使用S75脂质基PhytoSolve载有VEGF用于薄膜内膜治疗.
评估该系统在促进子宫内膜厚度和血管生成方面的有效性.

主要方法:

一种PhytoSolve配方 (S75脂化物,甘油,MCT油) 使用探头声波器进行准备.
在使用乙醇注射的雌性NMRI小鼠中诱导了薄型子宫内膜模型.
小鼠被分为治疗组,包括对照组,VEGF,PhytoSolve和VEGF/PhytoSolve.

主要成果:

该PhytoSolve配方的平均颗粒大小为67.57±7.07 nm.
从配方中释放的VEGF在24小时内初始释放了40%,随后每天持续释放.
与VEGF/PhytoSolve治疗组相比,VEGF/PhytoSolve治疗组显示子宫内膜厚度显著增加 (P<0.05).

结论:

含有VEGF的S75脂质基PhytoSolve是一种有效的系统,可促进血管形成和治疗薄型子宫内膜.
这种生物相容的药物输送系统对薄子宫内膜治疗和其他生物医学应用具有前景.

关键词:

这就是PhytoSolve的解决方案.一个薄的子宫内膜.在VEGF中,VEGF是VEGF.

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