在人类癌症中miR-765的作用
Asma'a H Mohamed1, Ayyub Ali Patel2, Waleed Al Abdulmonem3
1Biomedical Engineering Department, College of Engineering and Technologies, Al-Mustaqbal University, Babil 51001, Hilla, Iraq.
International immunopharmacology
|July 28, 2024
概括
微RNAs (miRNAs),包括miR-765,是癌症早期检测和治疗监测的重要生物标志物. 研究表明,miR-76565是一种
科学领域:
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 在瘤学瘤学.
背景情况:
- 微RNA (miRNA) 是参与基因调节和生物功能的短非编码RNA.
- 由miRNAs介导的表观遗传机制对于细胞过程至关重要.
- 异常miRNA表达与各种癌症有关,影响诊断和预后.
研究的目的:
- 审查miR-765在不同癌症类型中的分子和临床意义.
- 探索miR-765作为早期诊断和预后生物标记物的潜力.
- 要总结miR-765在癌症中影响的途径.
主要方法:
- 在癌症中调查miR-765的研究的文献综述.
- 分析与miR-765表达相关的分子和临床数据.
- 识别受miR-765.5影响的信号通路.
主要成果:
- 在不同癌症中,miR-765表现出不同的表达水平,这表明其作为瘤基因或瘤抑制剂的双重作用.
- miR-765影响关键的癌症相关途径,如PLP2/Notch,VEGFA/Akt1和ERK/EMT轴.
- 在miR-765水平的显著变化与癌症的发展和进展相关.
结论:
- miR-765作为一种有前途的生物标志物,用于早期检测各种癌症.
- miR-765显示出作为瘤发育,进展和转移的预测标记物的潜力.
- 对miR-765的进一步研究可以提高癌症诊断和治疗策略.
相关概念视频
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:38Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
01:06Induced Pluripotent Stem Cells
4.0K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.0K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:43Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K