多发性硬化症患者的骨损失和骨折:系统性审查和元分析
Mohammad Yazdan Panah1, Saeed Vaheb2, Elham Moases Ghaffary2
1Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
患有多发性硬化症的人患骨质疏松症,骨质疏松症和骨折的风险明显更高. 这一元分析强调了这一群体中骨健康问题日益增加.
科学领域:
- 神经学 神经学
- 整形外科 整形外科 整形外科
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 与骨矿物质密度 (BMD) 的降低有关.
- 患有多发性硬化症的人面临的骨折的风险更高,原因是骨质量下降,骨质疏松症和骨质疏松症.
- 这项研究探讨了MS (PwMS) 患者这些骨疾病的患病率和风险.
研究的目的:
- 调查多发性硬化症 (PwMS) 患者骨质疏松症,骨质疏松症和骨折的患病率.
- 评估与健康对照组相比,PwMS患者骨质疏松症,骨质疏松症和骨折的风险增加.
主要方法:
- 从2000年到2024年,在主要数据库 (PubMed/MEDLINE,Scopus,Embase,Web of Science) 中进行了系统的文献搜索.
- 在R软件中使用随机效应模型汇集数据并计算流行率,赔率比率 (OR) 和风险比率 (RR).
- 51项涉及1,503,785名PwMS的研究被纳入了元分析.
主要成果:
- 在PwMS中,骨质疏松症的综合患病率为41.41%,骨质疏松症为14.21%,整体骨折为12.84%.
- 与健康对照人群相比,PwMS显示骨质疏松症 (OR=2.02) 和骨质疏松症 (OR=1.71) 的可能性明显更高.
- 在PwMS中,整体骨折的风险也显著增加 (RR=1.86).
结论:
- 患有多发性硬化症的人患骨质疏松症 (2倍),骨质疏松症 (1.7倍) 和骨折 (1.9倍) 的风险大大增加.
- 这些发现强调了监测MS患者骨健康的重要性.
- 建议进一步进行精心设计的研究来探索这些关联.
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