精神分裂症家族高风险儿童的早期认知发展和精神病理学
Rebecca L Stephens1, Isabel Leavitt1, Emil Cornea1
1Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Schizophrenia research
|July 28, 2024
概括
患有精神分裂症家族高风险 (FHR) 的儿童早期表现出认知和行为缺陷. 这些发现强调了对幼儿的早期发现和干预的必要性.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿童精神病理学 儿童精神病理学
- 认知发展 认知发展
背景情况:
- 精神分裂症是一种带有认知缺陷的神经发育障碍.
- 以前关于儿童早期精神分裂症风险的研究已经产生了不一致的结果.
- 这项研究调查了1至6岁家庭高风险 (FHR) 儿童的认知发展和精神病理学.
研究的目的:
- 与对照人群相比,检查FHR儿童的认知发展和精神病理学.
- 确定FHR儿童在幼儿时代是否表现出一致的缺陷.
- 识别潜在干预的早期标志物.
主要方法:
- 评估FHR儿童 (n=33) 和对照组 (n=66) 的认知发展,使用穆伦早期学习量表 (1至2岁) 和斯坦福Binet,BRIEF-P/BRIEF,CANTAB (4至6岁).
- 在4岁和6岁时使用BASC-2评估心理病理.
- 采用一般线性模型和千平方分析来比较结果得分和得分资料.
主要成果:
- 在2岁时,FHR儿童的穆伦复合评分明显较低.
- 在4岁和6岁的FHR儿童中观察到智商,执行功能和工作记忆的广泛缺陷.
- 在4岁和6岁时,FHR儿童在大多数BASC-2项目上获得了明显较差的评分.
结论:
- 患有精神分裂症的儿童在FHR中表现出异常的认知发育和精神病理比以前发现的更早.
- 早期检测和干预策略应针对非常早期的儿童.
- 结果表明,在生命的头几年进行干预的关键窗口.
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